Regadenoson stress PET/CT MPI trumps SPECT for CAD detection

August 21, 2013

Regadenoson stress Rb-82 PET/CT myocardial perfusion imaging (MPI) is highly sensitive, 92 percent, for the detection of obstructive CAD and beats SPECT MPI, according to a study published online Aug. 12 in the Journal of Nuclear Medicine.

Edward Hsiao, MD, from the Noninvasive Cardiovascular Imaging Program and departments of medicine and radiology at Brigham and Women’s Hospital in Boston, and colleagues evaluated the vasodilator regadenoson with Rb-82 PET/CT MPI for the detection of both single- and multi-vessel obstructive CAD. Researchers also calculated stress left ventricular ejection fraction (LVEF) minus rest LVEF to define LVEF reserve. An estimation of injured myocardium was made using the Duke score. Previous findings cited in the study presented regadenoson as a superior choice for stress MPI also due to the convenience of bolus injection and compatibility with PET.