August 14, 2013
In cases of acute lung injury, pulmonary blood flow (PBF) provides potentially critical information about lung aeration. An FDG PET method of compartmental modeling may quantify PBF by estimating regional fraction of blood, a breath of fresh air for pulmonary imaging, according to a study published August 1 in the Journal of Nuclear Medicine.
Céline Pouzot, PhD, from the Clinic for Small Animal Emergency and Intensive Care Unit, VetAgro Sup, Campus Vétérinaire de Lyon in Marcy l’Etoile, France, and colleagues conducted a randomized and controlled preclinical study inducing acute lung injury in pigs followed by compartmental modeling of pulmonary FDG PET to see if fraction of blood was an effective method of evaluating PBF. Results showed high concurrence between PBF and blood fraction, potentially adding functionality to FDG PET studies of pulmonary inflammation.