Radioisotope therapy slowed metastatic pheochromocytoma, paraganglioma

August 13, 2013

A majority of 22 patients with metastatic, inoperable pheochromocytoma or paraganglioma had stable disease or complete resolution 6 months after receiving the first dose of treatment with the radioisotope 131I-meta-iodobenzylguanidine.

Treatment with 131I-meta-iodobenzylguanidine (131I-MIBG) appears to be safe and was associated with disease stabilization or improvement, which makes it a useful therapeutic tool either alone or with external beam radiotherapy and chemotherapy for patients with metastatic pheochromocytoma or paraganglioma, according to Dr. Matthew A. Rutherford of Glasgow (Scotland) Royal Infirmary and his associates.