PiB-PET scans show link between poor sleep and Alzheimer's

October 22, 2013

PET scans using the Pittsburgh Compound B (PiB) radiopharmaceutical have shown a potential link between poor sleep and greater beta-amyloid accumulation, which could lead to Alzheimer's disease in older adults, according to a study published online October 21 in JAMA Neurology.

The association between poor sleep quality and duration and beta-amyloid buildup was evident after researchers excluded participants with mild cognitive impairment or dementia, and it was also seen in subgroups with high or low PiB levels.

"Our results may have significant public health implications," wrote lead author Adam Spira, PhD, from the department of mental health at Johns Hopkins Bloomberg School of Public Health, and colleagues.