Imaging reveals brain changes 15 years before Alzheimer’s symptoms

July 16, 2012

PET imaging detected amyloid-beta (AB) deposition 15 years prior to expected onset of symptoms among persons with genetic mutations, predisposing them to autosomal-dominant Alzheimer’s disease, according to a study published July 12 in the New England Journal of Medicine. The researchers also reported concentrations of AB in cerebrospinal fluid (CSF) 25 years before symptom onset and increased tau protein in CSF 15 years prior to symptoms.