Pain Regulation Goes Awry in Fibromyalgia

November 15, 2012

The main pain inhibitory mechanisms in the brain may not function properly in fibromyalgia patients, researchers found.

Data from functional MRI (fMRI) and PET imaging studies suggest that the opioid system is involved in the pathogenesis of fibromyalgia, which may explain why some patients do not respond to, or experience worse symptoms with, narcotic analgesics, Richard Harris, PhD, of the University of Michigan in Ann Arbor, said in a presentation here at the American College of Rheumatology meeting.