Opioid-induced hyperalgesia might explain pain in fibromyalgia patients

December 4, 2012

Strong associations between evoked pain activations in patients with fibromyalgia were suggestive of hyperalgesia and mu-opioid receptor availability, according to research presented at the American College of Rheumatology Annual Meeting.

“Over the last decade it’s become more and more clear that the pain in fibromyalgia is probably due to changes in the central nervous system, more specifically, alterations in the way the brain actually functions,” researcher Richard E. Harris, PhD, assistant professor in the department of anesthesiology, Chronic Pain & Fatigue Research Center at the University of Michigan, said. “This definitely makes sense for subjective symptoms such as pain.