Rate of Brain Amyloid Accumulation Plateaus

February 28, 2013

Rates of amyloid build-up in the brain accelerate and then decelerate before reaching a plateau, providing a possible 15-year window of opportunity for intervention to prevent Alzheimer's disease (AD), according to a new study that used a sophisticated model to predict amyloid accumulation.

"To my knowledge, this is the first paper that proves in a mathematically sound way that amyloid accumulation follows this sigmoidal-shaped function with time," said lead author Clifford R. Jack, MD, a neuroradiologist and Alexander Family Professor of Alzheimer Disease Research, Mayo Clinic, Rochester, Minnesota.