C-11 acetate PET/CT helps patients before prostatectomy

May 7, 2013

PET/CT with carbon-11 (C-11) acetate is better at detecting lymph-node metastasis among patients planning for or completing radical prostatectomy than conventional imaging, and it can help predict treatment efficacy and survival, according to a study published in the May Journal of Nuclear Medicine.

While PET/CT's positive predictive value (PPV) was relatively low (49%), patients with false-positive PET results had a "significantly worse" prognosis than those with true-negative PET results. The relatively low PPV, the researchers speculated, might be due to inadequate lymph-node dissection or poor pathologic identification of positive nodes.