Patterns of amyloid plaque better signal slumping memory

July 18, 2013

Rather than looking at the global deposition of beta-amyloid in the brain, it may be more valuable to analyze its spatial pattern, now thought to have a stronger association with memory decline, according to a study published July 15 in Neurobiology of Aging .

Rachel A. Yotter, PhD, from the Center for Biomedical Image Computing and Analytics, University of Pennsylvania in Philadelphia, and colleagues used a new methodology to assess amyloid plaque deposition with C-11 PiB PET and found that the temporal progression of amyloid was more meaningful than total amyloid burden when assessing changes in cognition. Patients were grouped according to longitudinal alterations in memory performance. These subgroups were found to have substantially varying spatial patterns of amyloid deposition.